Why you need HCG if you are on testosterone therapy.

by West Conner · 103 comments

Let’s just get to the basics…

What is HCG?

HCG stands for Human Chorionic Gonadotropin.  It is medically used to induce ovulation in females and to stimulate testosterone production in males.  HCG requires a prescription and is injected into the subcutaneous fat or in the muscle tissue.

How does HCG work?

For this discussion, we will be focusing on the action in males.  HCG mimics leutenizing hormone (LH).  LH stimulates the Leydig cells in the testicles to produce testosterone.  This action also causes the testes to return to normal size and function if they were suppressed due to exogenous (from the outside) testosterone.

Who should use HCG?

Men who currently are on testosterone therapy should use HCG one week on and three weeks off.

What happens if I’m on testosterone and I don’t use HCG?

When your body has enough testosterone, the brain does not send the LH signal to your testicles.  Therefore, you will not make any testosterone until your levels drop to below normal and the signal returns, stimulating production.  Since you are getting testosterone from an outside source, your brain is most likely not sending that signal to your testicles.  Over time, the old adage of “use it or lose it” comes into play and your testicles will shrink in size.  The time is different for every man and the amount of “shrinkage” is different for every man.  Fortunately, the HCG will quickly restore the size and function.

Will HCG stimulate my own testosterone production?

Yes, but I wouldn’t recommend it.  Using HCG regularly over time will desensitize the Leydig cells to your own LH.  So when you stop the HCG, your testicles will not recognize the LH signal from your brain…not good.  HCG will increase your own testosterone for about five days after you inject it.

Will HCG stimulate estrogen production?

Yes.  When testosterone rises sharply, your body will aromatize the testosterone into estrogen.  This can be prevented with a tablet called anastrazole.  My patients take anastrazole anyway while on testosterone therapy.

Anything else I should know?

Of course…When you are on testosterone therapy, it is inevitable that your cholesterol level will go up.  Cholesterol is the beginning chemical structure for many of our hormones.  The enzyme that begins the changes of cholesterol into other hormones is stimulated by LH.  When taking testosterone, LH is suppressed.  When you inject the HCG, the enzyme is stimulated again and the pathway flows normally.

How to take HCG.

The dose I recommend is 500IU three times a week, one week on, three weeks off.  Usually, my patients inject the HCG during the first week of each month.  It gets injected just like a diabetic would inject insulin.  The level peaks in about 6 hours and remains at this level for 36 hours.  After about 72 hours, the level is back to baseline.

When my patients get their HCG from the pharmacy, it is freeze-dried and must be reconstituted with bacteriostatic water.  Everything comes ready to go in the kit.  You will draw 5ml of bacteriostatic water from the vial and inject it into the dried HCG vial.  DO NOT shake the HCG because the molecule is a peptide and is held together by weak carbon bonds.  Shaking can destroy the molecule.

Then draw 0.5ml of mixed HCG into the small insulin syringe provided.  Inject the HCG into the subcutaneous fat of your lower abdomen.  Store the HCG in the refrigerator after it is mixed.  The vial expires 30 days after mixing.

Using HCG while taking testosterone is important to maintain testicular size and function, help balance the other hormones needed in the body, and increases a man’s sense of well-being and libido.  As time goes on and research continues, we are learning more and more about how to properly use this wonderful hormone.


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