Why you need HCG if you are on testosterone therapy.

by West Conner · 99 comments

Let’s just get to the basics…

What is HCG?

HCG stands for Human Chorionic Gonadotropin.  It is medically used to induce ovulation in females and to stimulate testosterone production in males.  HCG requires a prescription and is injected into the subcutaneous fat or in the muscle tissue.

How does HCG work?

For this discussion, we will be focusing on the action in males.  HCG mimics leutenizing hormone (LH).  LH stimulates the Leydig cells in the testicles to produce testosterone.  This action also causes the testes to return to normal size and function if they were suppressed due to exogenous (from the outside) testosterone.

Who should use HCG?

Men who currently are on testosterone therapy should use HCG one week on and three weeks off.

What happens if I’m on testosterone and I don’t use HCG?

When your body has enough testosterone, the brain does not send the LH signal to your testicles.  Therefore, you will not make any testosterone until your levels drop to below normal and the signal returns, stimulating production.  Since you are getting testosterone from an outside source, your brain is most likely not sending that signal to your testicles.  Over time, the old adage of “use it or lose it” comes into play and your testicles will shrink in size.  The time is different for every man and the amount of “shrinkage” is different for every man.  Fortunately, the HCG will quickly restore the size and function.

Will HCG stimulate my own testosterone production?

Yes, but I wouldn’t recommend it.  Using HCG regularly over time will desensitize the Leydig cells to your own LH.  So when you stop the HCG, your testicles will not recognize the LH signal from your brain…not good.  HCG will increase your own testosterone for about five days after you inject it.

Will HCG stimulate estrogen production?

Yes.  When testosterone rises sharply, your body will aromatize the testosterone into estrogen.  This can be prevented with a tablet called anastrazole.  My patients take anastrazole anyway while on testosterone therapy.

Anything else I should know?

Of course…When you are on testosterone therapy, it is inevitable that your cholesterol level will go up.  Cholesterol is the beginning chemical structure for many of our hormones.  The enzyme that begins the changes of cholesterol into other hormones is stimulated by LH.  When taking testosterone, LH is suppressed.  When you inject the HCG, the enzyme is stimulated again and the pathway flows normally.

How to take HCG.

The dose I recommend is 500IU three times a week, one week on, three weeks off.  Usually, my patients inject the HCG during the first week of each month.  It gets injected just like a diabetic would inject insulin.  The level peaks in about 6 hours and remains at this level for 36 hours.  After about 72 hours, the level is back to baseline.

When my patients get their HCG from the pharmacy, it is freeze-dried and must be reconstituted with bacteriostatic water.  Everything comes ready to go in the kit.  You will draw 5ml of bacteriostatic water from the vial and inject it into the dried HCG vial.  DO NOT shake the HCG because the molecule is a peptide and is held together by weak carbon bonds.  Shaking can destroy the molecule.

Then draw 0.5ml of mixed HCG into the small insulin syringe provided.  Inject the HCG into the subcutaneous fat of your lower abdomen.  Store the HCG in the refrigerator after it is mixed.  The vial expires 30 days after mixing.

Using HCG while taking testosterone is important to maintain testicular size and function, help balance the other hormones needed in the body, and increases a man’s sense of well-being and libido.  As time goes on and research continues, we are learning more and more about how to properly use this wonderful hormone.


{ 96 comments… read them below or add one }

mike July 28, 2017 at 12:19 PM

hi doc, im a 50 year old male, i have been on the pellets and testo gel,but am now on the nabido injection. in all honesty,it has saved my life, lifted moods, more energy,and higher sex drive,.iv started injecting every 8 weeks now,…but now and again,i still get a awful trough,like where im so tired ache, and feel as if i have been run over,i could sleep for a week…..all i take is the injection,nothing else,i have been to doctors,to the endo at the hospital,and have even paid to go private,yet,still no body can help or know what to do..im at my wits end,..the trough either comes on just before my injection is due, or just after,such as now….just wondering if you have any advice……
many thanks mike


Kevin August 3, 2017 at 11:42 PM

Mike, you’re probably taxing your body with huge testosterone spikes and then it goes into somewhat of a withdrawal at the end. I am on trt with dr. John Crisler (lansing, mi) who is considered the expert of experts in this field. He has us on injections twice a week and I feel great. You might want to look him up. He does consults without prescribing over the telephone.


Don Washburn July 20, 2017 at 6:56 PM

My testosterone specialist has prescribed 1500mgs hcg 3 times per week open ended!
I was injecting cypionate for two years and started doing BioTe pellets last April.
Is this an appropriate amount of hcg for a 63 man?
Thanks for your site… very informative!


Anthony July 10, 2017 at 1:57 PM

Dr. I would like to hear your thoughts on my prescribed regime. I have been on .5cc(100mg) of cypionate per week for about 4 months. Recently sex drive has not been up to par and just not feeling the gains like when I first start my cycle. I have now been prescribed HCG at 1ml 3 times a week for two weeks at which point I will have blood work redrawn. My cypionate levels have also been decreased to .25cc a week. For the past couple of years I usually cycle on for 6 months and off for 6 months @100mg/per week of cypionate.


Anthony July 10, 2017 at 1:58 PM

where is says 1ml i meant to say 1cc^^^^


Ray July 5, 2017 at 2:07 PM

Hello Dr. Connor,

I am a 49yr old male who has been self diagnosed as suffering from the gross majority of the side effects of Low T for many years and had my blood work done in October 16′ by my local doctor. The first test came back with my Total Testosterone @ 442 ng/dL, Free Testostrone @ 47.2 pg/pL and Bioavailable Test @ 93.0 ng/dL. After that, I went to an Endocrinologist who repeated the tests. I don’t have the numbers with me, but in general his response was that my levels were within the acceptable range (for someone my age)and unless I wanted to pay out of pocket, he could not do anything or would submit to my insurance.

This has been super frustration as my libido has been nill for years, depression, lack of energy, increased body fat, muscle loss etc…

I am looking for any advise you can offer… Thank you!


Nick June 11, 2017 at 9:45 PM

Hello Dr. Connor,

I spoke to my Endo and he was not at all opposed to prescribing HCG. However, he said to inject it weekly. Right now I’m a bit confused because the prescription is for Follistim Aq. Is this what I should have expected? The cost is $9400 so I’m thinking there must be some kind of mistake also?

There are different ways HCG is prescribed?

Thank you,


John May 24, 2017 at 7:57 PM

Never had libido issues or erection issues until months after starting trt I take 75 mg of
Test cypionate per week my test level is 890 on the day that I inject.
Doctor doesn’t believe in hgc or arimedex
I stoped the cypionate and moved on to 50 mg of test propionate eod I’ve been on it for 2 years my test levels are about the same but my lipido is back my Bonner is back but not at 100% . I don’t have acne issues anymore. I’m 46 workout 5 times a week and very active. For me the propionate works better.
Can yo please shed some light on this issue. My doctor says it is me getting old.
I don’t buy it I didn’t have the issue until I started the trt.


Derek May 23, 2017 at 5:06 PM

I am here in Mesa Arizona. Where can I go to get a good doctor to write a prescription for this. I am currently on testosterone and my doctor does not believe in HCG.


Matt June 23, 2017 at 9:46 PM

Dr Gregory Allen is in Mesa AZ and is fantastic. He has 2 offices (Allen Family Medicine & Deseret Aesthetic Lifestyle Institute). I’ve been seeing him for years and am always impressed with his knowledge. He will help you out with any of your legitimate medical needs.


Keith April 21, 2017 at 9:55 PM


I’m about to start a regimen of hcg, Clomid and B12 shots. My testosterone levels are at 650 but my free T is low. I purchased a 6 month regimen. Is this a good idea as I’m fatigued all the time and am not responding to my work out regimen as I used to?

Thanks, Keith


Db May 5, 2017 at 2:38 PM

Hcg and clomid should not be run together. Clomid stimulates the hpta axis while hcg will supress it.


JOHN S April 17, 2017 at 11:46 AM



john n. vaughn March 8, 2017 at 6:40 AM

When u say draw 0.5 ml out for an hcg shot 3 times a week, then 3 weeks off, my question is i have 1ml or 100iu syringes, where is 0.5 on my syringe at?


Dr. Marc March 22, 2017 at 3:11 PM

0.5ml is the same as 50 units on the insulin syringe…which is a 1 ml syringe. mdj


john n. vaughn April 2, 2017 at 9:02 AM

Thanks! One more question? When i mix 10ml’s total at 500iu’s 3 times a week, is it ok to use all of it I’ve mixed? Cause i noticed where you say it expires after 30 days


john n. vaughn April 2, 2017 at 3:13 PM

Being its 1 week on and 3 weeks off. Is it ok to use all the hcg taking it this way as u explained


Rafiqul Islam February 22, 2017 at 1:18 PM

My LH is too high. What medicine should I take? Please give me a helpful advice


rajesh jajoo January 19, 2017 at 3:42 PM

My doctor is saying that my FSH(13) AND lh(13.5) is already high and hcg will not benefit.
do you agree ?


Bob January 13, 2017 at 1:28 AM

Dr.Conner,Following your proposed HCG schedule a 5cc vial would have to be discarded monthly after using 1.5ccs.What do you think of economizing by taking .5ccs three times per week every third week,or,even better injecting .5ccs three times on week one and injecting one full cc three times on week five on the supposition that the increased dose would compensate for the decreased strength of the solution?Thanks


Dr. Marc March 22, 2017 at 3:23 PM

HCG is not that fragile. It will last longer than 30 days. there are even reports that it is fine out of the refrigerator. There are a number of protocols for using HCG. All are based on preferences as there is no good research on what is the precise or “best” way to dose HCG. We do know that you don’t need much. Our clinic stimulates the testicles with HCG on a monthly basis. 1 month on/2 months off for most; 2 months on/1 month off for younger patients who plan to have children. We dose 0.5 ml twice a week for the month that the patient is using it. But I have clients on a 3 week on/1 week off protocol, 2 weeks on/2 weeks off protocol…all tailored to their symptoms. mdj


Jamie January 4, 2017 at 9:50 AM

Oh forgot to add that I’m at 900 MG a week of the test cyp


Jamie January 4, 2017 at 9:45 AM

I’ve been on test cyp 250 MG for 24 weeks. Will taking hcg bring my sperm count back up to normal while staying on the test? If so how long will it take for this to happen?


Dr. Marc March 22, 2017 at 3:27 PM

You seem to be on a very low dose. What are your levels. We recommend HCG for all our clients(except the very old or slow-release pellet patients that don’t care about testicular shrinkage) to preserve testicular function. If your spern counts are down, there are specific protocls to deal with that. Daily HCG for a month along with anastrozole, followed by clomid for at least three months. But most recommend stopping T if there are fertility issues. mdj


Robert Carozza August 5, 2017 at 6:47 AM

How is that a low dose?


Daniel November 21, 2016 at 11:14 AM

I have been using testosterone enanthate 200ML/ML at 1ml per week for 3 years. A month ago my balls started to hurt. Is there a process other than stop using
testosterone to stop this pain. I am 67 years old play hockey 3 days a week. I raise chickens and cows they need me everyday will withdrawal shut me down. I feel in good shape would like to continue with testosterone.


Derek November 19, 2016 at 12:04 AM

I am 20 years old and about a year ago I did a couple of cycles of test cypionate for 2 months. I took on month off and then did another cycle for a month. Since then I have had testicular atrophy and I get aches in my testicles. My doctor said I don’t have low test and no hernias or blockages. I’ve heard hcg will solve the pain and atrophy…?


Vito Goldfarb September 29, 2016 at 9:56 AM

I’m so confused! My urologist knew nothing about hormone balance and was slowly killing me…So I started with an outside company and self administers my shots I’m also using HCG Twife a week every week so reading on here that it should be used 1 week on and 3 weeks off has me very upset!! You’d think being able to get a positive solution to a problem that affects 100 of millions of men would be easy!! But it’s not easy at all!! If I was a Dr I’d specialize in this area.my question is I’m self injecting 100 mg testosterone cypionate once a week taking anastazole 3 timeso a week and injecting. 25 HCG twice a week why don’t I have a fucking libido???? I took myself off antidepressants hoping they were the culprit no change Godammit!! Somewhere someone must know how to fix this?? Please help!!! plundercosmic@gmail.com


Donovan September 16, 2016 at 3:32 AM

Hi there. i hope someone can help. My wife is using Testosterone injections for libido and it was AMAZING and couldnt of had a better sex life. However 3 months down the line the test injections are doing nothing anymore for the libido. Why has it stopped working?


MarkH July 26, 2016 at 10:56 AM

I recently started TRT and this is what I have been told to follow.

Day One: Testosterone Injection 1ml
Day Two: Nothing
Day Three: 0.5 Anastrozole taken orally
Day Four: Nothing
Day Five:0.5 Anastrozole taken orally
Day Six: HCG 25 units Subcutaneous Injection
Day Seven: HCG 25 units Subcutaneous Injection


Casey August 4, 2016 at 7:21 PM

i am on the exact same treatment plan as you are, except 180mg test cypionate. How have your results been? i went thru e.hormones, and paid 3 drand for a years worth of treatments. been on treatment now for 2 months, everything better except libido is only slightly improved. anybody have any suggestions? last blood draw showed my test at 1020, and estradial at 27. i am in great shape, dont drink, eat clean, and 35 years old.


Rob October 25, 2016 at 10:06 PM

Probably taking to much anastrazole….usually just one dose a week will suffice but everybody is different all you can do is discuss with your dr and tell him what your experiencing as detailed as possible….take notes if you have to… I take .70 ml of test cyp Saturday and again on Wednesday 1 – .5 mg of anastrazole on Saturday and my libido is more than my wife can handle….total test is around 1200 free test is a lil bit higher than they like but I feel great and no negative side effects….when total test was around 900 I had real bad acne on my back…after achieving that higher level acne disappeared within first week


Casey October 29, 2016 at 10:20 AM

thanks Rob! im also on the .25 hcg injection with insulin syringe twice weekly. Is this safe year round? ive heard conflicting views on whether you should use hcg the whole time while on trt. An.y advice would be greatly appreciated


Tray August 15, 2016 at 12:41 PM

Hey Casey, I am on 200 mg of test cyp every two weeks. I am not on anastrozole or HCG (yet). But I understand you’ve been on treatment for 2 months and having slow libido response. I started in May this year and went to my dr for my 2 month check up July 1st and also had the same problems and told him about all of that and he didn’t prescribe me anything but said just give the TRT time to work because it’s a treatment and a slow process. So I was a little disheartened he did nothing at that time, however, just about 3 weeks ago which would be almost 3 months after starting TRT, my libido went to normal and everything that goes with it! So don’t give up yet because it will come around, just give the treatment time. I wasn’t in great shape and still working on getting there. I drink sometimes. I eat pretty clean and I’m also 35 years old. Hope this helps you some and that you’ll give your treatment time to work even though it’s frustrating for you as it was for me (and my wife as well!). Good luck!


Casey October 29, 2016 at 10:12 AM

thanks Tray!


William January 16, 2017 at 9:46 PM

If your doctor is not giving you hcg. Find a new doctor. Seriously


David February 1, 2017 at 3:25 PM

This is the most stupid routine I’ve ever hurd,and 25iu hcg twice,thats not going to do nothing,especially at that dose and the way you’ve planned it out


Rob July 14, 2017 at 2:23 AM

The problem is when people say units or ml it doesn’t tell you the amount without knowing the concentration. It could be 250mg or 500mg. Who knows? The method of taking the hcg on day 6 and 7 is actually one of the studied and recommended methods I’ve seen research on. I’m not saying I recommend it just that it isn’t a made up schedule. I really don’t know one way or the other.


Brett May 12, 2016 at 9:24 PM

I’m glad I find this article. I need some advice and hopefully good news. I’m a 27 year old male, in shape athletic, use to take small dosages of steroids when I was earlier 20s. I never did anything too crazy or harsh (test enanthate mostly 500mg a week or less for 8 week to 12 weeks). About 3 years ago for curiousity I got my testosterone checked and it was something like 135 total. I had really no symptoms of low T. I still worked out, was muscular, had decent energy, and no sexual issues. I just ignored it and went on with life. About a year ago I got it tested again it was 175 total and still not any real symptoms. My doctor convinced me I crushed my test with doing moderate steroid cycles in the past. I refuse to believe this but I was put on test around a year ago. 1/2cc of cyp, levels were 600, then went to 1cc and levels shot over 1500 and lipids were a little out of whack so I’m going to ween back down to 1/2. I don’t want to be dependent on this and I’m awaiting an appointment with an Endo to see if and how I can come off and try to restore my natural test (hopefully higher than before) I think I just need a hard reset that i never had to get everything in motion. I want to gives this an honest balls to the shot before I succumb to TRT for life. I also have 1 son (3.5) conceived on a cycle and I’m wanting another. Please help, any advice I can take in with me or preemptily would be great!!!


Brett May 12, 2016 at 10:12 PM

Also, im not looking for free advice either. If necessary I’d be willing to set up a telephone consultation with any advice you could offer me. Possible outcomes, success rate, protocol, etc. thank you for your time Dr. Connor


Chris August 3, 2016 at 9:41 AM


Try Using clomid. Clomid suppresses the feedback loop to your brain signal in the pituitary to make LH and FSH which in turn produces testosterone and sperm. The only way this won’t work is if you have primary hypogonadism and your testicles done respond. I know because this is my case. I have never done steroids but I’ve been an athlete all my life when I discovered my body didn’t make the hormone. Hcg allows my testicles to produce sperm but my Ledig cells don’t respond to make testosterone. So I have to take external testosterone with hcg supplimentation. Good luck.


Pete September 27, 2016 at 2:14 PM

500 milligrams of testosterone enanthate is very strong weekly. The problem is most Physicians don’t prescribe the proper amount because a lot of people are obese have high blood pressure high cholesterol Etc. They are basically giving you half the dosage needed for testosterone replacement therapy. 200 milligrams weekly of testosterone cypionate is ideal, I doubt HCG will make much of a difference.


Stacy Methvin October 21, 2016 at 7:13 AM

My husband takes 10 mg and HCG and Sermorlin. Been on them for 6 months now and his energy level and libodo is back to where he was 20 years ago. He is 52, he weighted 267 when he started and is now 245. His T level was at 300 when he started. Is now at 700. Doc says a healthy level is 1000 or more.


rock March 29, 2016 at 4:36 AM


Someone told that HCG will also increase penis size is it true.

If we ll take it with GHT Gel .

After anabolic cycle my penis is shrinked. so i want to regain or enlarge or atleast increase my penis grith.

Please advice


Stacy Methvin October 21, 2016 at 7:14 AM

Not a doc, but my husbands did! He takes Testosterone, HCG and Sermorlin.


Nelson Vergel January 15, 2016 at 12:09 AM

Using HCG every other day at 500 IU plus TRT was shown to improve sperm count and quality by Lipshultz et al at Baylor. I am not sure why you would want to cycle HCG one week on and two weeks off. Desensitization does not occur specially at low doses.


Stacy Methvin October 21, 2016 at 7:16 AM

HCG stimlulates your natural ablilty to make Testosterone on your own. If you take testosterone by itself, then your body will think it doesn’t have to. 500mg is an awful lot! You might want a second opinion.


Phil December 20, 2015 at 8:46 PM

Hey I have a quick question
I’m 43 yr old male on .6ml (120mg) of test cup per wk, .5ml hcg per week and 1mg anastomosis per wk. I discovered after the clinic took me off hcg earlier this year I felt better than with it. I began injecting at home and hcg was in the prescription sent so i decided to try it again and felt horrible depression and feelings of emptiness. After the month of that I stopped and my energy levels returned. So my question is given that side effect and that fertility is not a concern for me, do you see any reason to take the hcg , do you think splitting the dose, or a lower dose could be beneficial
Thanks for your time


Roger December 3, 2016 at 6:42 PM

Do I really need to take hcg with my test shots of .50 ml. I’m 43 three kids no more wanted


Haley December 2, 2015 at 5:39 AM

Hi my name is Haley and I had a concern regarding my husband , my husband has been using anabolic steroids for a little over a year now without cycling off. we have been trying to get pregnant for a year as well he is 25 years old and currently takes injectable tren and test , he just received an order of hcg my question is will he be able to become fertile again and if so how long does it take for his body to regulate itself and how long should I expect to become pregnant ,


Joe January 28, 2016 at 6:24 PM

Yes got off a year and half cycle and 2 months later got my now wife pregnant..Clomid helps too.


Ron Depontie December 1, 2015 at 5:29 PM

Very interesting information here. I am 46 and I think my “T” is at about 240. I have had a little success with D Aspartic Acid and Tongkat Ali. But it has faded and now feeling pretty drained and low energy again. I am very much thinking about going to a Mens Clinic that provides T injections with HCG. I’m nervous to try it, but am thinking it’s worth a “shot” <–(pun intended)
I am not sure how things are going to go, I already have a slightly larger left chest that is noticeable if you look. But it's been there for the last 10 years. More noticeable when I've been working out though. I have tried creams, but only for about two weeks, then Dr. switched out to HcG tablets for about 30 days, then to HcG injections-think 100 per shot 1 x per week over 10 weeks. I think halfway through they must have started working as the energy increased and I tested at about 460. but they stopped after 10 weeks and suggested some other homeopathic options. Libido is OK, not ike it was, but I feel maybe 2X a week I get pretty horny still. Still have morning Erections, some days they are softer and shorter lived than others. So that's me. Advice?


Brian July 31, 2016 at 10:07 PM

Homeopathic anything doesn’t work, period


Stacy Methvin October 21, 2016 at 7:19 AM

Try Sermorlin as well as HCG with your testosterone injections.


Wade November 6, 2015 at 7:48 PM

Hi I’m taking 250mg of test enanthate weekly as TRT need some advice about HCG increasing my fertility as we are trying to conceive I’m 43 & without my TRT my levels are that of a school boy due to years of steroid abuse unfortunately. I’ve managed to get my wife pregnant twice this year but both ended in miscarriage. First was a shock as I’d been on TRT & did a short course of steroids. Second time I came off TRT but did not cope well. Not sure what to do to bring my sperm production back from the dead. Have had SA done and they were quiet bad but still managed to get my wife pregnant. Any idea on the dose of HCG that would benefit me with the amount of Test I take??


Wade November 6, 2015 at 7:42 PM

Hi I’m taking 250mg of test enanthate weekly how much HCG do I need to start taking to bring my sperm/fertility back on track if we are trying to concieve. We have managed to get pregnant twice this year already both ending in miscarriage. Last time I went of TRT cold turkey & it was awful. Want to know the best option for increased fertility I’m 43. Thanks


Rocky October 22, 2015 at 8:07 PM

Hello Doc, I have some concern about my T Therapary! I went To A Uroligist im 53 year old male! My T Was Low Total And Free! First blood text This December at my regular Docs Total Was 334 and my free was 7.5! So I found a Uroliogist That does It so it was like mid march and he took my blood for totals and free and my total was only 286 and my Free was only 4.3 it was Very low so i didnt do anything for a few month and started injecting only 1/2 ml Every 2 wks for a month and then he told me to do a 1 ml a wk so i started doing that so after 9 wks maybe 10 wks it went up to 486 and my Total and my free was 10.5 so its been going up! But i have friends that take the arimidex 3 to 4 times a wk .25 for the estrogen blocking so i got some and started taking the last few wks every other day! But my buddy who goes to a clinic get Hcg Shots 2 times a wk suppose to stop shrinkage of the Testies which i noticed mine are shrinking and my hair has been thinning to! So im not sure what to do my doctor never suggested either one i brought up but didnt perscribe it to me so can you please advise me what maybe i should do please thank you Rocky


Eddie September 17, 2015 at 8:39 PM

Hi Dr. Conner,
I have very low testosterone and also low levels of free testosterone. Is it safe to use HCG? I read about side effects, but I am not sure if they are common or rare. I’ve read that it can cause fatigue, irritability, restlessness, depression, fluid buildup (edema), and gynecomastia. Another serious concern is the risk of blood clots forming and blocking blood vessels. What is your opinion regarding this? I want to try it, but I am hesitant. Your comments are appreciated. Thanks


Brian September 17, 2015 at 10:30 AM

On 200 mg of testosterone per week taken 100 mg on tues morning and Friday pm for a total of 200 mg per week how much anastrozole would you recommend to start at generally?


mario July 18, 2015 at 2:00 PM

hello Doc,
im on T for about 2 years now I changed clinic and the new doc. put me on .5ml injection ones per week and .25ml x2 per week of hcg , my concern is that hcg causes blood cloth and strokes is that true?
thank you


AB July 9, 2015 at 5:06 PM

If i just got done with test. therapy and my levels have dropped due to LH signals… What should I do. My Test. level is at 84 now and my doctor said I should take HCG. However my doctor wants my levels around 800 min. – 1100 max. But i’m worried HCG will make all this worse when I stop taking it. What should I take.


Chris Northrup May 28, 2015 at 6:25 PM


I am 47. I have been on Test Cyp for 2 years now. Before I started taking it my issue was libido. It was non existent. I was put on 1.5ml once a week. My Test level went from 97 to over 1200 so they reduced the dosage to .8ml a week. Still libido in in the garbage. I feel no different on or off the Test Cyp. A lot of people claim they have a lot of energy, sex drive, weight loss, etc. Me I have none of that. In fact I put on 30 lbs. I am at a loss. Seems like most men are doing 3x the amount of Test Cyp that I am taking. I was also taking ant estrogen tabs at the same time. Did not notice anything different. Cant say I have Shrinkage at all but definitely libido is still not there and I would also say a lack of sensation as well. What would be a recommended Testosterone level for my age? What would HCG do for me that I am not getting now, if anything?




Jay July 21, 2015 at 9:17 AM

I have been on TRT for about 8 months now. I have varied my dosage several times and have included HCG and Anastrazole regularly. I could write more than a person will read, but with that said, i have noticed my libido change depending on where my E2 levels are. Too low of estrogen and libido is gone, too high same thing. Problem is finding the “sweet spot”. I have been lucky to hit it several times and am currently bouncing back and forth from one week to another ( which is good) because i am closing the gap. With all that said, it really has taken about 6-7 months to notice a major improvement in libido.


Brian May 22, 2015 at 1:04 PM

I’ve been on TRT for approximately 5 years, I am 53 and I cycle the Test cyp 10 weeks on and 3 weeks off, at a dose of usually 200ml/week. I use Arimidex to control E 1mg 2-3x/week. I have consistently noticed my libido peaks 3-4 weeks in my T cycle.. I would like to maintain that level all the time!! Would the Hcg injections help??


dirar May 17, 2015 at 1:40 AM

Iam 32 yrs old man married and I have 1 son 5 month ihave no libido weak erection
diagnose IHH I start sustanon 3 wk ago clomid 50 mg 2 month and im notice no improvement . Can I start HCG inj and if I start it for how long ineed to use it


Jay July 21, 2015 at 9:27 AM

Been there, i feel your pain. Good news is you can get that puppy up and running again, bad news it will take effort and some time. I have found that more frequent injections is better ( currently i am on EOD) , tried once a week, twice a week, and every third day, all had their own issues. I have had many blood tests and the total test and free test do best with every other day injections. I had weeks where my erections were good then soft and nothing. It has taken almost 6 months to see a major change in my libido. Good luck !!


Chris knutson May 2, 2015 at 7:44 AM

A new doctor I went to put me on hcg I had test levels of 668 post hcg and was tested several times over a year all being over 600 I told him I didn’t think I need the hcg I went on it anyway now my test levels are in the 300 range I’m very depressed I think I was lh desensitized I was taking it for 2.5 months via injection twice a week at 500mg per injection. Will my test levels come back to 600 again naturally or am I forever messed up?


jeff May 10, 2015 at 2:22 PM

500mg holy sht…


Glbtarin May 27, 2015 at 4:03 AM

500 iu’s twice weekly for 2 and a half months isn’t a long time. I doubt the HCG is responsible. Leydig cell desensitisation hasn’t been proven. You could bounce back but it sounds like hypogonadism to me. Personally I would consider TRT with HCG at 250iu’s twice a week and Test Enathate or Cypionate at 250mg per week.


Abraham Jose April 6, 2015 at 2:18 PM

I am on testosterone injections after a pituitary tumor surgery 13 years back. currently, on testosterone undeconate every 90 days for past 6 years. But, testicles shrunk too. I’ve been through HCG+HMG and natural testosterone shooted up (didn’t checked the value), and I became fertile too. What is worrying is, without any precautions taking Test.Undeconate will not be good for me as long as I wanted to remain fertile.(I’m married). So, Can you suggest what will be a good dose of HCG for me?


Abraham Jose April 15, 2015 at 4:43 PM

Hi Dr.West,
I was not clear in my early post. I am taking Nebido every 80-90 days. So, HCG dosage of 500IU three times on first week and on every three weeks ok? Please suggest when to do a blood test?

I had craniopharyngioma surgery done through nose and a remnant tumour is present which shows slight growth when I am NOT on testosterone or HCG+HMG combination.

I did a testosterone blood test after stopping HCG+HMG injections after a gap of 34 days and it came 16.93ng/dl (very low). So, my pituitary functions not good.


Jeff February 5, 2016 at 12:32 AM

Let me preface this by saying, I am not giving you medical advice. However, everything I am telling you can be verified by doing a quick google search of scholarly sources. Your test levels are very low, because your doctor is incompetent. 90% of your standard GPs and endos have no clue about TRT. The best place to go to is a TRT clinic. With “long acting” testosterone esters like enanthate and cypionate, you absolutely need to inject at least once a week to maintain steady levels of testosterone and avoid “shut-down” (extremely low testosterone). This is because the half-life of test E and Cyp is about 4-6 days. The half-life of test undeconate is about 15 days. This means that for it to work properly, you absolutely have to inject every 2 weeks at a minimum. If you are not timing the injections in a way that is commensurate with the ester, your levels will be much lower than they would be naturally, which leads to horrible side-effects. Unfortunately, most physicians either don’t bother to look at legitimate studies that prove this. You need to find a new doctor that knows what he/she is doing. Hopefully, you get this and I am really sorry for the side effects you are experiencing.


AT September 21, 2016 at 6:28 PM

I agree with you completely. What would you say are the best time to schedule the hcg injections and how many iu’s how often considering someone is doing 500mg Test E per week.


AT September 21, 2016 at 6:28 PM

for a 16 week period.


HCG User March 14, 2015 at 7:50 PM

Hello, Dr.

I’ve been taking HCG for virility for 1 year now and it has certainly been a huge help, BUT I would also like to lose weight as people do with the HCG diet.

My question is are there different types of HCG being sold out there? One pharmacy that filled my prescription seems to work great for upping my testosterone and sexual readiness, but the other really seemed to take off weight and inches around my waste.

Ideally, I’d like both of those things to happen. I’d like to lose 40 pounds and be ready for sex.

Any thoughts or recommendations on this?

I’m a 40 year old man, 225lbs at 6 feet tall.

Thanks in advance!


JF March 11, 2015 at 1:48 PM

If were to take 400mg a week of Test Cyp, how long before my LH and TSH would drop below normal levels w/out HCG alongside it?


J y February 28, 2015 at 10:43 AM

i take 1cc of test a week. I have been on test for a few years now. I just finished a 12 week cycle of EQ. Now I’m back to just taking my test what dosage of hcg should I take and for how long can I take it?


West Conner March 3, 2015 at 10:27 PM

500iu 3x a week, one week on, three weeks off taking as long as you are on testosterone


Alex February 25, 2015 at 9:23 AM

Interesting read. I am 22 and I used to take steroids well i was on test cyp and enanthate for about 5 to 6 weeks and I felt fine after taking nothing but letrzole, clomid and tamoxifen citrate for at least 5 weeks after I quit the test cold turkey. Well I’m afraid I have screwed up because I took hcg to make my testes grow back to normal size but now I have very low libido and extremely weak erections. Will my test levels return back to normal or must I go through TRT? If I do have to go through TRT is it something I’ll have to do for life?


West Conner March 3, 2015 at 10:27 PM

At 22 years old, you should come back. It may take some time depending on you and your TRT dosing. Give it time.


Stephen Miller February 18, 2015 at 1:56 PM

I have been taking TRT for several years. Recently my wife and I decided to have a child so I went to a fertility Dr. She had me stop the TRT and I have been on clomid for around 5 months. My T levels are at around 100 – I just started taking HCG 2000 IU 3x’s a week –
If I took the TRT WITH the HCG would it help ramp up my levels or should I only be taking the HCG?



West Conner March 3, 2015 at 10:25 PM

The TRT will significantly decrease fertility. HCG will bring it back to normal in most cases. I think 2000IU 3x a week is way too frequent, but check with a fertility expert on that dosing. Fertility dosing is not my expertise. Don’t use testosterone if you are trying to get pregnant.


Chris Wiebe February 16, 2015 at 12:49 PM

Dr. West Conner, question on this subject, I have found HCG to be ineffective (pharmacy graded /prescription) during TRT(150mg cyp a week).. of course I followed exactly what you are talking about here, I dosed 500IU 3/4 times a week even 100IU subq daily, never saved me… still got “shrinkage” after about 4 weeks.. and of course its not fun.. so it keeps me from doing long duration TRT..I have had better luck with menopur at holding off testicle atrophy during trt, is this something you have seen before? or course I wish HCG did work for me as it does for many of my friends, because its so inexpensive compared to menopur.. could I be a non responder? I have tried it at least 3 times straight from the pharmacy for short durations 2-3 weeks mid TRT period…, in my blood work the LH is at .5 or lower even with HCG supplementation..menopur slightly higher ( 75 IU 3 times a week) would it be showing as LH in a blood test?.. or does it not equate to the body’s LH.. appreciated in advance


West Conner March 3, 2015 at 10:22 PM


My only thought is that you could just not respond to HCG. If that is the case, you are the first person I’ve heard of that happening to. I’d try using HCG fro a different pharmacy. I’ve seen some pretty “shady” stuff out there. Hopefully that will work for you because that Menopur is so expensive.


Jeev January 22, 2015 at 9:24 PM

Hello doctor ,
I have been using testesterone enthanate of300 mg every week for
Last 5 years for bodybuilding . Now i have stopped it and am on clomid for 5
Months . My sperm count was at 0 which now has improved to 3 million
My test levels have reached 250 and is stagnant with out any improvement
What would u suggest i do .
Kindly advice


Thomas December 26, 2014 at 8:55 PM

Marc – I have been on TRT for 1 year.
Every 3 days I take the following
50 mg depo
500 iu’s HCG
Everything is going great and I feel fine.
My most recent blood work is a follows
Estradiol 15
Free Test: 153
Total Test: 1011
I have had 7 blood tests through out the last year all aprox the same.

However, I have noticed what would appear to be a slight increase of fatty tissue around the lower portion of my pectorals. My concern is this may be the beginning of Gynecomastia.

I have read that HCG could be a contributing factor to this.

Do you think following your recommended dosage of 1 week on 3 weeks off of HCG would be advisable? And would, or should I see a decrease in the fatty tissue on my lower pectorals because of this action?
Or would you suggest another actions?


paul December 3, 2014 at 9:11 AM

I would like to see the study that says hcg desensitizes the leydig cells to real lh


West Conner December 26, 2014 at 5:13 PM


There have been studies. When given large, frequent doses, the HCG will desensitize the cells. The dose I recommend does not adversely effect the Leydig cell receptor sites. The dose can be high and infrequent or low and frequent without desensitization. Infrequent higher dosing gives better results in my opinion.


kevin April 29, 2016 at 6:03 PM

I have also seen the studies, I have also seen a study were a very high dose of hcg alone is enough to downregulate the receptors. I have been on trt for over a year now, and things have hit a rough patch. Going on trt was amazing, more energy, libido etc. However as the months went on It has been getting harder and harder to orgasm and now it is damn near impossible. My wife feels she Is no longer attractive, and it has caused a rift in our love life. I recently started 1000iu twice a week under my dr, for 3 weeks. Then down to 300iu twice a week. Can you please tell me how long it will be till the sensitivity comes back? Things are terrible right now! Any advice or help would be very very appreciated!


Dan November 30, 2014 at 4:11 PM

I am a 55 year old male. I have been on a 200 mg/mL injection of testosterone for a little over a year now and have noticed testicular shrinkage. I just went for my annual check up and shared with my doctor your thoughts on HCG in combination with TRT and she said she has never given any patient both and wouldn’t do it.

Does anyone know any doctors in the NYC or Connecticut areas that believe in the benefits of both hormones?

Please recommend someone who understands.



West Conner December 26, 2014 at 5:11 PM


I don’t know of a doctor in those states. Your “doctor” is completely wrong, I’d find someone else who can treat you ASAP.


Randy May 15, 2015 at 1:34 AM

Hi Dan,

I might be able to help you. Although, I’m hoping that you still come back to this website looking for information. Anyway, my name is Randy and I currently live in Yonkers, NY. The endocrinologist I see has an office in Yonkers (Tues/Thu 1pm-4pm) and the Bronx (Mon/Wed/Fri 9am-noon). I’ve been seeing him for 10 years now, due to being diagnosed with Secondary Hypogonadism at 22 years old. I’m now 35. I get test cyp, anastrozole, synthroid scripts from him and recently started to get HCG script.

Definitely shoot me an email rlt1980@hotmail.com and I’ll be more than happy to provide reference. To protect his privacy, I’d rather not give his name and number out in the open. Hope you get this.



rob September 9, 2014 at 12:51 PM

I turned 32 today…5 months ago I had my hormone levels checked and my testosterone 289!….that’s the natural level of a 78 year old man…..I now take 100 mg of test 2 times a week and I take a hcg tab that dissolves in your mouth 3 times a week and arimidex 2 times a week….I feel like a kid again and my wife loves the revived libido….I now want to go outside with my 2 and 3 year old sons and play till they drop….I’m feeling 1 million times better than 5 months ago so for me it’s a no brainer….take these meds and stick yourself in the leg to be the husband and father that my family deserves!


rob September 9, 2014 at 12:43 PM

At your age if you stop taking the test and hcg….you are gonna stop playing tennis and golf and your libido is gonna plummet and so will your overall sense of well being and health. Your 51 and your worried about taking for the rest of your life….well your life span will be greatly increased because of these meds so you will take them longer , yes. However consider the alternative of a shorter more miserable life without them. There had to be a reason why you were prescribed these in the first place. The hassle of 1 shot or two a couple times a week adding years and happiness to my life sounds like an even trade to me.


Marc September 4, 2014 at 8:41 AM

Great article, thank you. I have a question… I’m considering going completely off Testosterone and HCG and was wonder what the best protocol would be. I currently take 140 mg (0.7 cc) of Cypionate on Fridays each week and take .5ML of HCG on Sunday, Tuesday, and Thursday. I recently added the HCG approximately 7 weeks ago but have been on Cypionate for about 1.5 years.

I play competitive tennis and also enjoy golf working out ….I have seen very positive improvements in my body including lower fat levels, greater strength, and faster recovery time. However, I’m concerned about taking these drugs for the rest of my life (I’m 51). As a result, I am considering going off.

What are your recommendations… think quoting is a good idea? IF I do want to quit, can I just stop both cold turkey since I’ve been on HCG for 7 weeks?

Thanks very much!


West Conner December 26, 2014 at 5:08 PM


At that dose, you can quit “cold turkey” and the testosterone will leave your body. Id continue HCG for a couple months just to be sure you are producing something. You will notice a difference when you stop, trust me.


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